Long-term Follow-up Of Childhood Cerebellar Astrocytomas After Incomplete Resection With Particular Reference To Arrested Growth Or Spontaneous Tumour Regression

Abstract

The long-term prognosis for incompletely excised benign cerebellar astrocytomas in children remains largely unpredictable as the incidence of symptomatic recurrence ranges from 18 to 100%. Arrested growth and spontaneous tumour regression are a recognized but neglected phenomenon, the incidence and objective demonstration of which have received relatively little attention in the literature. With the aim of providing more information on this question, we reviewed our experience with incompletely resected benign cerebellar astrocytomas in children. As hypothesized by Cushing, our study shows that a large proportion of cerebellar astrocytomas do not progress or even regress after partial excision. This phenomenon is not understood and unfortunately cannot be anticipated. However, it suggests that a policy of "wait and see" with serial MR imaging can reasonably be recommended in children with cerebellar astrocytoma after partial resection, if the remnant is too risky to be removed by second-look surgery