Spontaneous Visual Improvement In Chiasmal Gliomas
Liu, G. T., & Lessell, S. (1992). spontaneous visual improvement in chiasmal gliomas. American journal of ophthalmology, 114(2), 193–201. https://doi.org/10.1016/s0002-9394(14)73984-4
View Original Source →Abstract
Three untreated patients with presumed chiasmal gliomas had spontaneous visual improvement, although serial magnetic resonance imaging in two of the patients showed the lesions to be unchanged. Two patients had evidence of neurofibromatosis. Three other patients with similar disease courses have been documented in the medical literature. These cases demonstrate that conservative management of optic chiasmal gliomas may sometimes be associated with favorable outcomes.
Case Details
Disease Location
Right optic nerve glioma
Personal Characteristics
22-year-old female, history of megacephaly, multiple cafe au lait spots, no family history.
Clinical Characteristics
22-year-old female referred for chiasmatic tumor. Megacephaly and cafe au lait spots present but no nf history in family. Lisch nodules bilateral. Visual defect present. Follow up exam at 6 months, 15 months unchanged. No treatment given. At 24yo age, visual acuity improved however visual field improved. MRI confirmed a suprachiasmatic mass with extension into right optic n. A small focus seen in cerebellum. At 26yo age, improved vision and visual field defects. MRI unchanged. Last follow up at 27to age.
Remission Characteristics
No treatment given. At 24yo age, visual acuity improved however visual field improved. MRI confirmed a suprachiasmatic mass with extension into right optic nerve. A small focus was seen in the cerebellum. At 26yo age, improved vision and visual field defects. MRI unchanged. Last follow up at 27yo age.
Treatment & Mechanisms
Proposed Remission Mechanisms
Possible tumor cell necrosis or immune mechanism
Clinical Treatment
None reported
Non-Clinical Treatment
None reported