Decrease Of E-cadherin Expression In Canine Cutaneous Histiocytoma Appears To Be Related To Its Spontaneous Regression

Abstract

BACKGROUND: Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression. MATERIALS AND METHODS: E-cadherin immunoexpression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, representing different stages of tumour regression. RESULTS: All tumours expressed membranous E-cadherin both in keratinocytes, and in tumoural cells and no differences were noted among the histological groups analysed. However, the intensity of the E-cadherin immunolabeling decreased in the presence of lymphoid infiltration and varied significantly among the groups considered (p<0.0001). CONCLUSION: This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression. The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression.