Spontaneous Remission Of A Non-small Cell Lung Cancer Possibly Caused By Anti-ny-eso-1 Immunity
Nakamura, Y., Noguchi, Y., Satoh, E., Uenaka, A., Sato, S., Kitazaki, T., . . . Kohno, S. (2009). Spontaneous remission of a non-small cell lung cancer possibly caused by anti-NY-ESO-1 immunity. Lung Cancer (Amsterdam, Netherlands), 65(1), 119-122. doi:10.1016/j.lungcan.2008.12.020
View Original Source →Abstract
Spontaneous remission of malignant tumors is rare and the biological mechanism of such remission has not been addressed. We report the case of a 71-year-old Japanese patient with non-small cell lung cancer with a right hilar tumor and pleural dissemination that spontaneously regressed. NY-ESO-1 is a cancer/testis antigen that can elicit specific immune responses in patients with cancer. Strong anti-NY-ESO-1 immunity was detected in this patient. His tumor cells expressed NY-ESO-1 and MHC class I molecules. Anti-NY-ESO-1 immunity might have contributed to spontaneous remission in this patient.
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