Spontaneous Regression Of Small Cell Lung Carcinoma And Associated Hemichorea
Shibata, K., Nishimura, Y., & Sakura, H. (2021). Spontaneous Regression of Small Cell Lung Carcinoma and Associated Hemichorea. Internal medicine (Tokyo, Japan), 60(23), 3817–3821. https://doi.org/10.2169/internalmedicine.7190-21
View Original Source →Abstract
The spontaneous regression (SR) of cancer is defined as either partial or complete, and temporary or permanent, disappearance without appropriate treatment for the disease, and this phenomenon is rare in the case of small cell lung carcinoma (SCLC). We herein report an 83-year-old woman who presented with left-sided hemichorea associated with anti-SOX1 (SOX1-Ab) and -CV2/CRMP5 (CV2/CRMP5-Ab) antibodies with SR following a 7-year interval free of disease progression of SCLC. Hemichorea can present with the coexistence of anti-SOX1 and CV2/CRMP5-Ab with SR after a long interval free of SCLC. The immune response associated with these onco-neural antibodies may become independent of the original tumor trigger and remain active for many years.
Case Details
Disease Location
Lung
Personal Characteristics
83-year-old woman
Clinical Characteristics
Investigated for a cough that persisted several months. Chest computed tomography (CT) revealed abnormal hilar masses of the mediastinum. An elevated level of gastrin-releasing peptide precursor, and tumor sampling of the paratracheal lymph node confirmed the diagnosis of small cell lung carcinoma (sclc).
Remission Characteristics
7 years later, chest CT and PET scans revealed no evidence of any original abnormal hilar lesions and no signs of primary or metastatic tumors
Treatment & Mechanisms
Clinical Treatment
Biopsy