Spontaneous Regressions In Non-small Cell Lung Cancer With Different Clinical Outcomes
Yamamoto, M., Iizuka, S., Otsuki, Y., & Nakamura, T. (2022). Spontaneous regressions in non-small cell lung cancer with different clinical outcomes. International journal of surgery case reports, 92, 106812. https://doi.org/10.1016/j.ijscr.2022.106812
View Original Source →Abstract
INTRODUCTION AND IMPORTANCE: Spontaneous regression (SR) of cancer is extremely rare in non-small cell lung cancer and the exact pathogenesis is unclear. CASE PRESENTATIONS: A 69-year-old man underwent a right upper lobectomy for a squamous cell carcinoma histologically confirmed 8 weeks prior. A histopathological examination of the surgical specimen revealed no viable cancer. He remains disease free at 5 years after surgery. A 77-year-old man presented with a metastatic bone tumor compatible with a non-small cell lung cancer origin. He had undergone a surgical biopsy for a right lung nodule of which the histopathological examination revealed only scar tissue a year prior. He died of cancer 4 months after the diagnosis of a bone metastasis. CLINICAL DISCUSSION: The unknown etiology of an SR of cancer is still to be resolved. CONCLUSION: Patients with an SR of cancer may yield a variety of clinical outcomes and a meticulous observation is essential.
Case Details
Disease Location
Lung
Personal Characteristics
69-year-old man, 16-year history of rheumatoid arthritis
Clinical Characteristics
Presented with a right lung mass. Transbronchial lung biopsy revealed a poorly differentiated carcinoma consistent with a squamous cell carcinoma. A right upper lobectomy was performed 8 weeks after the biopsy
Remission Characteristics
A histopathological examination of the surgical specimen revealed only a few atypical squamous cells in the necrotic tissue without any viable tumor cells
Treatment & Mechanisms
Clinical Treatment
Biopsy
Non-Clinical Treatment
None reported