Vanishing Liver Tumours.
Peddu, P., Huang, D., Kane, P. A., Karani, J. B., & Knisely, A. S. (2008). Vanishing liver tumours. Clinical radiology, 63(3), 329–339. https://doi.org/10.1016/j.crad.2007.08.009
View Original Source →Abstract
Spontaneous resolution of liver tumours is a rare, but recognized entity that has been reported to occur within the spectrum of benign and malignant liver tumours occurring in both adult and paediatric population. The aetiology of this unusual phenomenon is not clearly understood. In this article we present case examples of various benign and malignant liver tumours that have regressed spontaneously without treatment together with a review of the literature, and a summary of the current understanding of the pathogenesis of these tumours.
Case Details
Disease Location
Liver
Personal Characteristics
32-year-old woman, she had given birth 4 years before and had thereafter been taking an oral contraceptive containing 0.25 mg d-norgestrel and 0.05 mg ethinyl oestradiol
Clinical Characteristics
Intermittent vague upper abdominal pain. Us demonstrated a 42 mm focal lesion in the right lobe of the liver. CT demonstrated a solitary hyperdense nodule measuring 42 mm on the arterial phase images, which was isodense to the rest of the liver parenchyma on the portal venous phase images. Oral contraceptives were discontinued.
Remission Characteristics
MRI with manganese performed 18 months after initial presentation demonstrated a marked reduction in the size of the adenoma, which measured 24 mm. Further follow-up MRI at 4 years demonstrated a normal liver with complete resolution of the tumour
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed
Clinical Treatment
Oral contraceptives discontinuation