Spontaneous Remission Of Adult Acute Myeloid Leukemia With T(8;16)(p11;p13)/moz-cbp Fusion
Hoshino, T., Taki, T., Takada, S., Hatsumi, N., & Sakura, T. (2018). Spontaneous remission of adult acute myeloid leukemia with t(8;16)(p11;p13)/MOZ-CBP fusion. Leukemia & lymphoma, 59(1), 253–255. https://doi.org/10.1080/10428194.2017.1320712
View Original Source →Abstract
The translocation t(8;16)(p11;p13), which results in fusion of the MOZ/MYST3/KAT6A gene (8p11) and CBP/CREBBP gene (16p13), is characterized by unique morphologic and clinical findings in acute mye...
Case Details
Disease Location
Bone marrow
Personal Characteristics
49-year-old woman
Clinical Characteristics
Presented with a very high white blood cell (wbc) count, mild anemia, and thrombocytopenia. Lactate dehydrogenase (ldh) was elevated. Bone marrow aspiration revealed hypercellularity with 52.0% blasts, which showed a monocytic appearance with heavy granulation upon dual myeloperoxidase and nonspecific esterase cytochemical staining. A cytogenetic analysis revealed 46,xx,t(8;16)(p11;p13) as the sole karyotypic abnormality in 17 of 20 metaphases. Rt-pcr detected moz-cbp type i chimeric transcript.
Remission Characteristics
She spontaneously underwent complete remission (cr) 7 days after diagnosis of the disease and stayed in remission. Bone marrow 4 months after diagnosis still revealed cr, cytogenetic analysis of the bone marrow cells revealed the normal karyotype, and minimal residual disease was not detected.
Treatment & Mechanisms
Proposed Remission Mechanisms
None reported
Clinical Treatment
None before remission
Non-Clinical Treatment
None reported