Spontaneous Regression Of Hepatocellular Carcinoma: Three Case Reports And A Categorized Review Of The Literature.
Oquiñena, S., Iñarrairaegui, M., Vila, J. J., Alegre, F., Zozaya, J. M., & Sangro, B. (2009). spontaneous regression of hepatocellular carcinoma: three case reports and a categorized review of the literature. Digestive diseases and sciences, 54(5), 1147–1153. https://doi.org/10.1007/s10620-008-0447-z
View Original Source →Case Details
Disease Location
Liver
Personal Characteristics
60-year-old male, diagnosed with familiar hemochromatosis in 2000
Clinical Characteristics
In september 2003 increased levels of AFP (66 ui/ml) were found on routine follow-up and CT and MRI showed a mass in the right lobe of the liver that invaded the main portal vein and had typical imaging features of hcc. In february 2004 he started treatment with oxaliplatin and gemcitabine without response after 4 cycles.
Remission Characteristics
In june 2004, MRI scan showed a clear, nonmeasurable volume regression of the tumoral thrombus that was confirmed in october 2004 when a new MRI scan failed to show any distinct focal liver lesion and AFP was normal.
Treatment & Mechanisms
Proposed Remission Mechanisms
Disturbance in hepatic circulation associated with portal vein thrombosis
Clinical Treatment
Oxaliplatin and gemcitabine
Additional Notes
authors claim regression is not attributable to chemotherapy