Spontaneous Regression Of Hodgkin Lymphoma: Case Report And Review Of The Literature
Pasvolsky, O., Berger, T., Bernstine, H., Hayman, L., Raanani, P., & Vidal, L. (2019). Spontaneous Regression of Hodgkin Lymphoma: Case Report and Review of the Literature. Acta haematologica, 141(1), 14–18. https://doi.org/10.1159/000494422
View Original Source →Abstract
Spontaneous regression of Hodgkin lymphoma (HL) is a rare event. We describe a 32-year-old woman with spontaneous regression of HL and review the literature. The patient presented with cervical lymphadenopathy and was diagnosed with stage IIA classical HL. The patient refused to receive any treatment for her disease. Positron emission tomography/computed tomography carried out 2 years later showed complete regression of the lymphadenopathy, without pathological uptake of fluorodeoxyglucose. At the last follow-up, 3.5 years after the initial presentation, the patient is with no evidence of disease. During workup for the HL, concomitant papillary thyroid carcinoma was diagnosed, for which the patient refused treatment as well. The thyroid malignancy has remained stable throughout the follow-up.
Case Details
Disease Location
Lymph nodes
Personal Characteristics
32-year-old woman
Clinical Characteristics
Presented with left cervical lymphadenopathy. Fine needle aspiration of the lymph node revealed several cells suspicious for reed-sternberg cells (rscs). An excisional biopsy was performed, revealing classical hl, nodular sclerosis type, grade 1. Chromogenic in situ hybridization for epstein-barr virus (cish eber) was positive in many cells. PET/CT revealed increased pathological uptake of fdg of high intensity (deauville score of 4) in lymph nodes measuring up to 1.5 cm in the left neck, and intermediate intensity fdg uptake in retropectoral and left axillary lymph nodes measuring up to 1.2 cm.
Remission Characteristics
2 years after diagnosis, PET-CT showed complete regression of the lymphadenopathy, without pathology- cal uptake of fdg
Treatment & Mechanisms
Clinical Treatment
Biopsy
Non-Clinical Treatment
None reported