Spontaneous Regression Of Primary Endobronchial Extranodal Marginal Zone Lymphoma Of Mucosa-associated Lymphoid Tissue
Hosoda, C., Ishiguro, T., Takahashi, N., Kamiishi, N., Shimizu, Y., & Takayanagi, N. (2019). Spontaneous regression of primary endobronchial extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. Respiratory medicine case reports, 27, 100826. https://doi.org/10.1016/j.rmcr.2019.100826
View Original Source →Abstract
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of pulmonary origin is a relatively rare disease. In particular, reports of MALT lymphoma occurring and localized in the trachea or bronchus have been limited. Pulmonary MALT lymphoma has been reported to demonstrate spontaneous regression, whereas there is only one reported case of spontaneous regression of primary endobronchial MALT lymphoma. We herein report the case of a 70-year-old man with primary endobronchial MALT lymphoma who showed spontaneous regression with an interest of endobronchial findings.
Case Details
Disease Location
Bronchi
Personal Characteristics
70-year-old man, smoker (1 pack/day for 50 years)
Clinical Characteristics
Presented for cough as his symptoms did not improve in over a month. CT showed thickening of the bronchovascular bundle and stenosis at the introitus of the middle lobar branch. Bronchoscopy showed several endobronchial nodular protrusions and bronchial thickening along the right middle bronchus. During the second bronchoscopy a histology sample of an endobronchial biopsy specimen was compatible with a diagnosis of malt lymphoma. Sleeve lobectomy of the right middle lobe was performed. The bronchus intermedius was found to have a protruded lesion (10 × 5 mm). The final diagnosis was low-grade b cell malt lymphoma.
Remission Characteristics
A second ronchoscopy was performed again to obtain sufficient material to confirm the pathological diagnosis, and the endobronchial lesions were found to have regressed while the mucosal surface appeared relatively regular without atrophy or stenosis
Treatment & Mechanisms
Clinical Treatment
Biopsy, lobectomy
Non-Clinical Treatment
None reported