Complete Spontaneous Regression Of Hepatosplenic T-cell Lymphoma After Surgical Biopsy
Nakamoto, R., Okuyama, C., & Oka, S. (2020). Complete Spontaneous Regression of Hepatosplenic T-Cell Lymphoma After Surgical Biopsy. Clinical nuclear medicine, 45(2), e88–e91. https://doi.org/10.1097/RLU.0000000000002782
View Original Source →Abstract
F-FDG PET/CT for a 74-year-old man with elevated serum soluble interleukin 2 receptor showed multiple intense uptake in the liver, spleen, and bone. A surgical biopsy from 2 of liver tumors confirmed hepatosplenic αβ T-cell lymphoma. One and a half months after biopsy, FDG PET scan was performed again for staging before starting chemotherapy, and it showed the complete disappearance of all of the lesions. The excisional biopsy could be a possible trigger of his spontaneous regression.
Case Details
Disease Location
Liver, spleen, bone
Personal Characteristics
74-year-old man
Clinical Characteristics
Right abdominal pain that had begun 1 week previously. CT scan revealed multiple low-density lesions in the area of the liver and spleen. Elevation of serum soluble interleukin-2 receptor (sil-2r) (1804 u/ml) was observed and malignant lymphoma was suspected. PET/CT scan findings were consistent with those detected in CT. Bone lesions were also found. Laparoscopic enucleation of tumors in the right hepatic lobe was performed to confirm the histological type of lymphoma. The patient was diagnosed with hepatosplenic αβ t-cell lymphoma (hstcl).
Remission Characteristics
One and a half months later, he underwent a PET/CT scan no significant fdg uptake was seen in nontreated tumor sites where the first PET/CT scan had demonstrated abnormal fdg uptake. Decrease of serum sil-2r (619 u/ml) was observed
Treatment & Mechanisms
Proposed Remission Mechanisms
Tumor-associated molecular and patient-induced immunologic mechanisms could work together to induce tumor regression.
Clinical Treatment
Laparoscopy
Non-Clinical Treatment
None reported