Long-term Spontaneous Regression Of Stage Iv Diffuse Large B-cell Lymphoma
Furukawa, Y., Ando, J., Ando, M., Kinoshita, S., Edahiro, Y., Furuta, T., Ohshima, K., & Komatsu, N. (2021). Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma. Journal of clinical and experimental hematopathology : JCEH, 61(3), 168–172. https://doi.org/10.3960/jslrt.21002
View Original Source →Abstract
Diffuse large B cell lymphoma (DLBCL) is an aggressive disorder accounting for >30% of all lymphomas. Its prognosis is poor due to a high relapse rate. Spontaneous regression (SR) in DLBCL is rare, with only a few reported cases. Moreover, almost all of these were low-grade lymphomas with an average SR duration of 13 mo. As the cause of SR is unknown, there are many theories such as trauma, infection, medication, and an antitumor immune response. We present a patient with progressive DLBCL who demonstrated SR for >42 mo. Although treatment for lymphoma usually starts soon after diagnosis, insights into SR of lymphomas may lead to new treatment strategies.
Case Details
Disease Location
Vagina, right lung
Personal Characteristics
76-year-old woman, history of gastric adenocarcinoma that was treated surgically
Clinical Characteristics
Consulted for vulvar discomfort. Simple digital examina- tion revealed a 3 cm mass in the anterior wall of the vagina centered on a point 2 cm from the vaginal introitus and 7 cm from the cervix, with protrusion into the lumen. Vaginal and abdominal sonography demonstrated blood flow in the mass. 3 months after the first visit, a PET-CT revealed uptake in the vagina and in the right lung (middle lobe). Histopathologic examination of a core needle biopsy specimen from the vaginal mass indicated the diagnosis of diffuse large b cell lymphoma (dlbcl)
Remission Characteristics
1 year later, a CT revealed no lesions in the pelvic soft tissues or the right lung.
Treatment & Mechanisms
Clinical Treatment
Biopsy
Non-Clinical Treatment
None reported