Spontaneous regression of primary cutaneous diffuse large B-cell lymphoma, leg type after biopsy

Case Details

Disease Location

Skin

Personal Characteristics

62-year-old man

Clinical Characteristics

One month-long history of five painless nodules on his left leg. Initially appeared as small red papules, which rapidly increased in size and depth within a few days. He underwent a biopsy in a local hospital, but no conclusive diagnosis was established. He was treated with topical corticosteroids with no improvement. Physical examination revealed five erythematous, indurated nodules measuring 1–4 cm in diameter aggregated on the posteromedial side of his left leg. Histopathological examination of a second biopsy revealed dense infiltrate of large lymphoid cells throughout the dermis and subcutis. The bone marrow examination showed no evidence of malignancy. The diagnosis of primary cutaneous diffuse large b-cell lymphoma, leg type was made

Remission Characteristics

At 3 months from the first visit, the tumours had undergone almost complete resolution, leaving slight post inflammatory hyperpigmentation

Treatment & Mechanisms

Proposed Remission Mechanisms

It is possible that the injury and secondary inflammation of the local tissue induced by biopsy might have contributed to the anti- tumour process.

Clinical Treatment

Corticosteroids, biopsy, bone marrow biopsy.

Non-Clinical Treatment

None reported