Spontaneous Regression Of Recurrent Hepatocellular Carcinoma After Tae: Possible Mechanisms Of Immune Mediation.
Nakai, T., Shimomura, T., & Hirokawa, F. (2001). spontaneous regression of recurrent hepatocellular carcinoma after TAE: possible mechanisms of immune mediation. International journal of clinical oncology, 6(3), 149–152. https://doi.org/10.1007/pl00012098
View Original Source →Abstract
We report findings in a 76-year-old man who underwent a lateral segmentectomy of the liver for hepatocellular carcinoma in July 1996. In July 1997, transarterial embolization (TAE) was performed for recurrent tumors in the remnant liver. Augmentation of the tumors and an increase in protein induced by vitamin K absence or antagonist (PIVKA)-II level were noted in October 1997, and, although we recommended TAE again, the patient and his family refused further treatment. Subsequently, the patient was only observed, and, except for a small lesion that was probably a scar, no tumors were noted on image examinations in November 1998, and the PIVKA-II level had returned to a normal value at this time. Two years after the regression, the tumors appeared to be in complete spontaneous remission. This patient had no history indicative of ischemic necrosis, and levels of cellular surface markers for natural killer (NK) cells and NK cell activity showed high values, which suggested that tumor immunity was activated by some, unknown, mechanism.
Case Details
Disease Location
Liver
Personal Characteristics
76-year-old man with liver cirrhosis caused by the hepatitis c virus
Clinical Characteristics
Lateral segmentectomy of the liver, for hcc, classified as stage iii (t3n0m0) according to the TNM, tae was performed for multiple recurrent tumors in the remnant liver. In october 1997, the tumors showed augmentation, and the level of pivka-ii was high. On october 23, 1997, CT showed multiple tumors, approximately 3cm in diameter, in s1, s4, and s5 of the liver.
Remission Characteristics
On abdominal CT in october 1998, no tumors were noted, except for a small lesion that was probably a scar, and the pivka-ii level was normalized
Treatment & Mechanisms
Proposed Remission Mechanisms
Immunological mechanism.
Clinical Treatment
Lateral segmentectomy of the liver, for hcc, classified as stage iii (t3n0m0) according to the TNM. Ransarterial embolization (tae) was performed for multiple recurrent tumors in the remnant liver.