Spontaneous Remission Of Genetic, Apparent Primary, Fsgs Presenting With Nephrotic Syndrome Challenges Traditional Notions Of Primary Fsgs
Oo, S. Z. M. W. H., Freese, M. E., Holanda, D. G., & Thomas, C. P. (2021). Spontaneous remission of genetic, apparent primary, FSGS presenting with nephrotic syndrome challenges traditional notions of primary FSGS. Journal of nephrology, 34(1), 255–258. https://doi.org/10.1007/s40620-020-00837-7
View Original Source →Case Details
Disease Location
Kidney
Personal Characteristics
26-year-old caucasian female
Clinical Characteristics
Referred for new-onset nephrotic syndrome (ns). She developed bilateral leg swelling followed by swelling of her arms and face. About 2 weeks into her leg swelling, she was seen by nephrology, WHO noted peripheral edema, lower serum albumin, and an elevated urine protein creatinine ratio (upc). She was started on furosemide. She underwent a kidney biopsy that showed focal and segmental glomerulosclerosis (fsgs) in 2 out of 47 glomeruli, with focal mild interstitial fibrosis and tubular atrophy, and severe diffuse foot process effacement (fpe) on em. She was started on lisinopril genetic screening showed that she had a heterozygous missense variant in transient receptor potential cation channel subfamily c member 6 (trpc6), she was diagnosed with autosomal dominant fsgs,
Remission Characteristics
Her peripheral edema improved, her proteinuria resolved, and her serum albumin normalized.
Treatment & Mechanisms
Clinical Treatment
Lisinopril, furosemide