Spontaneous Regression Of Mismatch Repair-deficient Colon Cancer: A Case Series
Yokota, T., Saito, Y., Takamaru, H., Sekine, S., Nakajima, T., Yamada, M., Sakamoto, T., Taniguchi, H., Kushima, R., Tsukamoto, S., Shida, D., Kanemitsu, Y., & Matsuda, T. (2021). Spontaneous Regression of Mismatch Repair-Deficient Colon Cancer: A Case Series. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 19(8), 1720–1722.e3. https://doi.org/10.1016/j.cgh.2020.08.051
View Original Source →Abstract
Spontaneous regression of cancer is a rare phenomenon, with 33 colorectal cancer cases reported between 1900 and 2020.1-4 Spontaneous regression is defined as the partial or complete disappearance of a tumor without treatment.1,3 Several factors may be involved in this process, including biopsy, mechanical stress, humoral factors, and infection.1,5 However, no concrete evidence for the mechanistic insights has been indicated.
Case Details
Disease Location
Transverse colon
Personal Characteristics
64-year-old man. History of peptic ulcer, diabetes. Family history of stomach cancer
Clinical Characteristics
Presented with positive fobt. A 20 mm tumor was found in the transverse colon. Biopsy was performed. Histologic findings showed a tubular adenocarcinoma, moderately differentiated 42 days later, right hemicolectomy with d3 lymphadenectomy was performed
Remission Characteristics
Histologic findings of the resected specimen showed granulation tissue and foreign-body giant cells
Treatment & Mechanisms
Proposed Remission Mechanisms
Antitumor immune reaction, which is activated by unidentified triggers, might underlie the tumor regression.
Clinical Treatment
Biopsy