Spontaneous Regression Of Mismatch Repair-deficient Colon Cancer: A Case Series
Yokota, T., Saito, Y., Takamaru, H., Sekine, S., Nakajima, T., Yamada, M., Sakamoto, T., Taniguchi, H., Kushima, R., Tsukamoto, S., Shida, D., Kanemitsu, Y., & Matsuda, T. (2021). Spontaneous Regression of Mismatch Repair-Deficient Colon Cancer: A Case Series. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 19(8), 1720–1722.e3. https://doi.org/10.1016/j.cgh.2020.08.051
View Original Source →Abstract
Spontaneous regression of cancer is a rare phenomenon, with 33 colorectal cancer cases reported between 1900 and 2020.1-4 Spontaneous regression is defined as the partial or complete disappearance of a tumor without treatment.1,3 Several factors may be involved in this process, including biopsy, mechanical stress, humoral factors, and infection.1,5 However, no concrete evidence for the mechanistic insights has been indicated.
Case Details
Disease Location
Transverse colon
Personal Characteristics
76-year-old woman. History of diabetes and glaucoma
Clinical Characteristics
Presented with positive fobt. A 10 mm tumor was found in the transverse colon. Endoscopic tattooing was performed. Histologic findings showed a moderately differentiated tubular adenocarcinoma 52 days later, laparoscopic right hemicolectomy with d2 lymphadenectomy was performed
Remission Characteristics
Histologic findings of the resected specimen showed a fibrotic scar and mucin lake
Treatment & Mechanisms
Proposed Remission Mechanisms
Antitumor immune reaction, which is activated by unidentified triggers, might underlie the tumor regression.
Clinical Treatment
Biopsy