Spontaneous Clearance Of Chronic Delta Hepatitis
Kapuria, D., Ben Yakov, G., Koh, C., & Heller, T. (2020). Spontaneous Clearance of Chronic Delta Hepatitis. Hepatology (Baltimore, Md.), 71(5), 1873–1875. https://doi.org/10.1002/hep.31073
View Original Source →Abstract
1Liver Disease BranchNational Institutes of HealthBethesdaMD 2Department of GastroenterologyUniversity of New MexicoAlbuquerqueNM * Address Correspondence and Reprint Requests to: Devika Kapuria, M.D. Department of Gastroenterology, MSC 10‐5550 1 University of New Mexico Albuquerque, NM 87131 E‐mail: [email protected] Tel.: +1‐505‐272‐4205
Case Details
Disease Location
Liver
Personal Characteristics
48-year-old male. History of hepatitis b infection and chronic hepatitis d
Clinical Characteristics
His alanine aminotransferase (alt) levels were elevated. His platelet count was low. A computed tomography scan of the abdomen showed nodularity and borderline splenomegaly. Initial liver biopsy showed chronic hepatitis d (chd) with positive staining for hepatitis d antigen, marked viral activity, and portal fibrotic expansion
Remission Characteristics
3 years later, on a routine follow-up, he tested negative for hdv RNA. Liver biopsy a year after clearance of hdv showed improvement in inflammation, with no hepatitis d antigen detected on staining.
Treatment & Mechanisms
Proposed Remission Mechanisms
A plausible mechanism could be increased expression of interferon-stimulated genes leading to a robust innate immune response.
Clinical Treatment
Biopsy