Unilateral Breast Mass In An Infant: A Rare Presentation Of Spontaneously Regressing M-year-old Femaleibromatosis
Al-Jazaeri, A., Al-Zahem, A., Al-Maziad, H., Kfouri, H., Al-Boukai, A., & Al-Sultan, A. (2010). Unilateral breast mass in an infant: a rare presentation of spontaneously regressing m-year-old femaleibromatosis. Journal of pediatric surgery, 45(9), 1896–1899. https://doi.org/10.1016/j.jpedsurg.2010.05.027
View Original Source →Abstract
Breast tumors are very rare in infants. We describe a 4-month-old female infant who presented with a firm and painless right breast mass. It was first noticed at the age of 1 month and then gradually increased in size. Further physical examination and imaging studies revealed other subcutaneous masses and lytic bone lesions. True-cut biopsy from the breast lesion was consistent with infantile myofibromatosis. Infantile myofibromatosis is a group of uncommon mesenchymal tumors that tend to occur in infancy and regress spontaneously, as demonstrated in our case. Surgical excision of such lesion might have led to permanent loss of breast tissue. The report discusses the clinical, radiological, and pathologic features, in addition to the previously described treatment options for this condition.
Case Details
Disease Location
Right breast with metastases to bone marrow of right humerus
Personal Characteristics
Four- months-old female otherwise healthy familial health unremarkable
Clinical Characteristics
Right breast with metastases to bone marrow of right humerus on MRI biopsy from breast lesion showed biphasic cellular pattern and spindle cell proliferation with minimum mitotic activities without pleomorphism or atypia in the remaining tissues, less differentiated plump polygonal to round cells were seen arranged around thin branching blood vessels. Focal paucicellular areas with stromal hyalinization were also noted. Both spindle and plump cells (+) actin (+) vimentin (-) desmin (-) s-100
Remission Characteristics
Examination 12 months post diagnosis revealed significantly smaller breast mass; lateral chest wall mass and palpable MRI 18 months post diagnosis showed a significantly smaller breast mass MRI 18 months post diagnosis showed regression of breast lesion to approximately 1/2 previous size and disappearance of left chest wall and right humerus lesions
Treatment & Mechanisms
Proposed Remission Mechanisms
A possible host response to the tumor or its products. Intracytoplasmic debris in ‘healed’ ducts and their propagation to non‐fibrotic neoplastic ducts possibly due to a secondary inflammatory phenomenon.
Clinical Treatment
None reported reported