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Primary Malignant Tumors Of The Long Bones End-results In One Hundred And Seventy Operable Cases

Coley, W. 1927Sarcoma

COLEY WB, COLEY BL. PRIMARY MALIGNANT TUMORS OF THE LONG BONES: END-RESULTS IN ONE HUNDRED AND SEVENTY OPERABLE CASES. Arch Surg. 1927;14(1):63–141. doi:10.1001/archsurg.1927.01130130067005

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Abstract

Breast cancer remains a worldwide public health dilemma and is currently the most common tumour in the globe. Awareness of breast cancer, public attentiveness, and advancement in breast imaging has made a positive impact on recognition and screening of breast cancer. Breast cancer is life-threatening disease in females and the leading cause of mortality among women population. For the previous two decades, studies related to the breast cancer has guided to astonishing advancement in our understanding of the breast cancer, resulting in further proficient treatments. Amongst all the malignant diseases, breast cancer is considered as one of the leading cause of death in post menopausal women accounting for 23% of all cancer deaths. It is a global issue now, but still it is diagnosed in their advanced stages due to the negligence of women regarding the self inspection and clinical examination of the breast. This review addresses anatomy of the breast, risk factors, epidemiology of breast cancer, pathogenesis of breast cancer, stages of breast cancer, diagnostic investigations and treatment including chemotherapy, surgery, targeted therapies, hormone replacement therapy, radiation therapy, complementary therapies, gene therapy and stem-cell therapy etc for breast cancer.

Case Details

Disease Location

Left tibia

Personal Characteristics

27-year-old male

Clinical Characteristics

Operation conducted & prompt recurrence occurred second operation performed (incision & curetting of bone) diagnosed as spindle cell sarcoma tumor recurred, measuring 3 by 4 inches, 2 ulcerations over central portion

Remission Characteristics

Tumor rapidly subsided & bone cavity healed in restored health 37 years after original presentation

Treatment & Mechanisms

Clinical Treatment

Mixed toxins of erysipelas & bacillus prodigiosus for 2 mths