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Prognosis And Treatment Of Giant-cell Sarcoma: Based On A Further Study Of End Results In Sixty-nine Cases

Coley & Coley, 1927Sarcoma

Coley W. B. (1927). PROGNOSIS AND TREATMENT OF GIANT-CELL SARCOMA: BASED ON A further STUDY OF END RESULTS IN SIXTY-NINE CASES. Annals of surgery, 86(5), 641–665. https://doi.org/10.1097/00000658-192711000-00002

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Abstract

STUDIES of majorTs a 1 ivary-gland tumors based on signifi-( antly large numbers of cases.T h e tumors geneially are uncommon and certain of the many types extremely rare.Hence, in few institutions will there be sufficient material for full evaluation of even the more commonly recognized varieties.Tumors of the salivary glands have few rivals in histological diversification.I n the present study the pathological material and clinical records of nearly nine hundred cases were carefully reviewed.These were accumulated during a twenty-year period ending in 1949.Chief emphasis was placed upon histological classification and analysis of the natural history of the separate tumor types under conditions of clinical managelllent in which surgical treatment was highly accented.Detailed discussion of the technical methods of treatment has not been attempted.In Table 1 is a listing of the separate histological varieties and their distribution within the three major salivary glands.Each of these types will be individually discussed with the exception of the sebaceous-c ell adenoina and unclassified tumors.There was a single example of a possible sebaceous-cell adenoma.This tumor (Figs.178, 179) wa4 a centimeter in diameter, encapsulated, and made u p of sebaceous-like cells of a sort occasionally E ~~i i i d in salivary glands.T h e entire tumor was embedded so that staining €or fat was not possible.Hence, the listing of a single example of this tumor type is more an anticipation, than a proof, of its actual existence.T h e unclassified tumors were almost entirely f i om cases

Case Details

Disease Location

Left tibia at junction of middle and upper thirds

Personal Characteristics

27- year-old male

Clinical Characteristics

Swelling of left tibia at junction of middle and upper thirds (burgeoning in size) operation conducted recurrence occurred second operation conducted (incision & curetting of bone) tissue diagnosed as spindle cell sarcoma tumor recurred & measured 3 by 4 inches with an ill-defined border

Remission Characteristics

Tumor rapidly disappeared and bone cavity healed with healthy granulations after 2 mths of mixed toxin administration healthy thirighty-seven years after original presentation

Treatment & Mechanisms

Proposed Remission Mechanisms

Mechanism is unknown

Clinical Treatment

Mixed toxins of erysipelas and bacillus prodigiosus administered for 2 months