Variable Problems In Lymphomas
Parekh, S., Heberight, T., Ratech, H., & Sparano, J. (2005). Variable problems in lymphomas: CASE 3. spontaneous regression of HIV-associated Burkitt's lymphoma of the cecum. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 23(31), 8116–8117. https://doi.org/10.1200/JCO.2005.08.079
View Original Source →Case Details
Disease Location
Cecum
Personal Characteristics
47 -year-old male history of HIV
Clinical Characteristics
Presented with bloody diarrhea and 30 lb weight loss was taking medication for the last for 4 years and his CD4 count was 350 u/l with an undetectable viral load, his only previous HIV-related illness was oral thrush physical exam was significant for bilateral axillary adenopathy measuring 1 to 2cm. CT scan of the abdomen and pelvis showed a cecal mass, hepatomegaly and renal cysts colonoscopy revealed a circumferential multiobated mass above the ileocecal junction. Biopsy revealed burkitt-type high-grade b-cell lymphoma. Biopsy of right axillary adenopathy showed reactive hyperplasia, but no evidence of lymphoma and the serum lactose dehydrogenase level was not elevated the patient sought alternative option and returned 3 months later repeat abdomen CT was performed and found regression the antiretroviral regimen was unchanged, CD4 count was 330 u/l and viral load was still undetectable
Remission Characteristics
When returning 3 months later, an abdominal CT showed regression of the cecal mass, colonoscopy confirmed a significant decrease in the mass biopsy showed a florid reactive polyclonal b and t-lymphocyte hyperplasia without evidence of lymphoma remains alive and well with no evidence after 5 and a half years since initial presentation
Treatment & Mechanisms
Proposed Remission Mechanisms
May be most likely due to the antiretroviral treatment for HIV previous cases of maxillary burkitt's lymphoma saw regression after injections of septiceme
Clinical Treatment
Had been taking stavudine, ritonavir, saquinavir, and didanosine for 4 years
Non-Clinical Treatment
None reported