spontaneous remission of bilateral conjuctival Extranodal Marginal Zone B-Cell lymphoma of Mucosa-Associated Lymphoid tissue

Case Details

Disease Location

Bilateral conjunctive

Personal Characteristics

72 -year-old male may 2004 had tuberculosis as during childhood

Clinical Characteristics

Presented with redness of both eyes for a week in 2004 best-corrected visual acuity was 1.2 in both eyes, thickened sal months-pink lesion extended from the lower fornix to bulbar conjunctiva and to the upper fornix involving the whole circumference in the right eye, while the lesion was restricted to the lower fornix in the left eye anterior segments and fundi of both eyes were normal, MRI showed no lesions in bilateral orbit, and gallium scan revealed no abnormally high uptake sites a plain chest x-ray demonstrated fascicular shadows in the bilateral lung fields with thickened pleura of the right lung apex and the dull cardiopulmonary angle in the left lung, suggestive of prior tuberculosis blood tests were normal conjunctival sac culture detected corynebacterium species and methicillin-sensitive staphylococcus aureus in both eyes in june 2004, excisional biopsy took place in both eyes and used ofloxacin eye drops as preventive antibiotics and betamethasone eye drops as an anti-inflammatory for a month post-op CT scan of the chest after the biopsy showed nodular and fascicular shadows of the bilateral lung fields with pleural thickening and calcification the radiation therapy planned for the residual conjunctival lesion in the right eye was postponed after the diagnosis of recurrent pulmonary tuberculosis, the patient underwent a standard three-drug regimen for 6 months starting november 2004. Method for tissue biopsy treatment in article histopathological exam revealed medium-sized lymphoid cells in vage nodular patterns. A fraction of lymphoid cells showed differentiation to plasma cells and had dutcher bodies, immunohistochemical stains showed lymphoid cells positive for cd79a, but negative for CD3, 5, 10, and 20. The lymphoid cells in the lesions of both eyes shared an immunoglobulin kappa monotype was classified as extranodal marginal zone b-cell lymphoma of mucosa-associated lymphoid tissue (malt)

Remission Characteristics

The residual conjunctival lesions in both eyes gradually regressed and disappeared completely in two years. Repeat gallium scan showed no evidence of lesions systemically

Treatment & Mechanisms

Proposed Remission Mechanisms

Anti-tuberculous agents might suppress chronic inflammation or eradicate other factors that facilitate lymphoma growth ofloxacin after excisional biopsy might play a role in the induction of sr

Clinical Treatment

Excisional biopsy oflaxacin, and betamethasone eye drops isoniazid, rifampicin, and ethambutal (3-drug regiment for tb)

Non-Clinical Treatment

None reported