Spontaneous Regression Of Extranodal Malignant Lymphoma Occurred In The Gingiva
Koga, M., Kusukawa, J., & Hayabuchi, N. (2003). spontaneous regression of extranodal malignant lymphoma occurred in the gingiva. Oral oncology, 39(3), 323–324. https://doi.org/10.1016/s1368-8375(02)00122-7
View Original Source →Abstract
The spontaneous regression of malignant neoplasm is an extremely rare event. Here we report a case of extranodal malignant lymphoma occurring in the upper gingiva, which regressed spontaneously. A 78-year-old female had noticed a diffuse bucco-lingual swelling of the left maxillary gingiva in the incisor regions for a month, and she visited our department on 20 January 1999. Intraoral examination revealed diffuse swelling and redness in the maxillary gingiva of the incisor regions. Cervical and underarm lymphadenopathy was not detected. Surgical biopsy of the swollen gingiva revealed a malignant lymphoma, with diffuse large cells, B cell type. She was clinically staged as IE. After biopsy, the tumor spontaneously decreased in size; finally, the mass completely disappeared after 3 weeks. After regression, the lesions were externally irradiated with 30 Gy total dose. The patient has been free from disease for 36 months after regression.
Case Details
Disease Location
Gingiva (left maxillary)
Personal Characteristics
78 -year-old female january 1999 in 1995 had a partial resection of the right upper alveolus from the canine to the second premolar due to squamous cell carcinoma of the gingiva
Clinical Characteristics
Patient presented with 1- months history of diffuse bucco-lingual swelling of the left maxillary gingiva in the incisor regions, this mass gradually increased in size intraoral exam reveal bucco-palatal swelling of the gingiva extending from canine to canine, the mass was elastic firm and covered with normal but reddish mucosa. Incisors in the lesion showed no abnormal movement incisional biopsy of swollen gingiva was performed the biopsy found malignant lymphoma with diffuse large cells of b cell type, physical exam revealed no peripheral lymph nodes were palpable in any regions and no abnormalities were found, there were no cervical or underarm lymphadenopathy and the diagnosis was staged as ie
Remission Characteristics
After the biopsy, the swollen gingiva decreased in size the mass completely disappeared 3 weeks after the biopsy she has remained disease for 36 months
Treatment & Mechanisms
Proposed Remission Mechanisms
Tumor immunity was activated by the surgical intervention an immunological response by the host
Clinical Treatment
After regression, she was irradiated with 2 gy/day for 15 days
Non-Clinical Treatment
None reported