Spontaneous Regression Of Intraocular Lymphoma
Kase, S., Namba, K., Jin, X. H., Kubota, K. C., & Ishida, S. (2012). spontaneous regression of intraocular lymphoma. Ophthalmology, 119(5), 1083–1084. https://doi.org/10.1016/j.ophtha.2011.12.011
View Original Source →Case Details
Disease Location
Intraocular (left eye)
Personal Characteristics
80 -year-old male april 2010
Clinical Characteristics
Patient was complaining of blurred vision in his left eye (os) ophthalmological findings were hypopyon and bitreous opacity os, the right eye was normal infectious endophthalmitis or uveitis was suspected thus the patient was prescribed systemic antibiotics and corticosteroids but the symptoms didnt improve in october 2010, vitrectomy including silicon oil tamponade was conducted since an elevated retinal lesion was noted and was referred in november 2010 visual acuity worsened from counting fingers to hand motions slit-lamp exam demonstrated corneal epithelial edema without hypopyon os, fundus exam revealed an irregular-shaped yellowish elevated lesion with retinal hemorrhage located in the superior region of the optic disc concentration of IL-10, in vitreous samples in october were 2111 pg/ml. Monoclonality of igh gene rearrangement was confirmed with polymerase chain reaction method. Vitrectomy was performed to collect vitreous fluid submitted for cytological examination on january 2011. Cytology showed atypical lymphoid cells with a high nuclear/cytoplasm ratio findings led to a diagnosis of intraocular lymphoma (iol) systemic evaluation by imaging modalities and lumbar puncture displayed no abnormalities except in the left eye, after vitrectomy, the visual acuity became no light perception, 2 weeks after the final vitrectomy, enucleation was performed os central cut section of the enucleated eye demonstrated an elevated lesion near the optic disc and retinal detachment. Histological section of the elevated lesion marked cell infiltration predominantly in the subretinal space. At high magnification, small lymphoid cells inflitrated the subretinal space with no cellular atypia, even in deeper cut sections a variety of small lymphoid cells were positive for CD20, also CD8-ppositive t lmphocytes massively infiltrated the subretinal space monoclonality of igh gene rearrangement was not observed in DNA isolated from the paraffin-embedded eyeball section
Remission Characteristics
After enucleation, there was no systemic metastases or recurrence for 8 months
Treatment & Mechanisms
Proposed Remission Mechanisms
CD8+ t cells are one of the possible factors responsible for the sr of iol
Clinical Treatment
Systemic antibiotics and corticosteroids
Non-Clinical Treatment
None reported