Primary Cutaneous Anaplastic Cd30+ Large-cell Lymphoma That Completely Regressed After Incisional Skin Biopsy
Gencoglan, G., Ozturk, F., Inanir, I., Miskioglu, M., Temiz, P., & Gunduz, K. (2010). Primary cutaneous anaplastic CD30+ large-cell lymphoma that completely regressed after incisional skin biopsy. Cutaneous and Ocular Toxicology, 30(2), 163–166. https://doi.org/10.3109/15569527.2010.534749
View Original Source →Abstract
We describe a 48-year-old woman with three erythematous nodules localized on the left forearm, with 2 months evolution. Histological and immunohistochemical examination revealed a CD30(+) large-cell lymphoma. Systemic involvement was not detected. The tumor regressed spontaneously within a week, after the incisional skin biopsy. In control skin biopsy, there was not any histological feature of lymphoma. No reactivation or any symptom of systemic disease was observed during the 10-month follow-up period.
Case Details
Disease Location
Erythematous nodules on left forearm
Personal Characteristics
48 -year-old woman 1 month history of painless, asymptomatic, erythematous nodules on the left forearm no family history of lymphoproliferative disorders
Clinical Characteristics
Primary cutaneous anaplastic CD30+ large t-cell lymphoma dermatological exam of the three erythematous nodules revealed a diameter of 3-5mm localized to the left forearm, there were no other skin lesions. Neither lymphadenopathy nor hepatosplenomegaly was detected complete blood count and peripheral blood smear were normal, histopathological exam of the incisional biopsy of the lesional skin revealed a diffuse non-epidermotropic dermal infiltrate that was composed of large atypical lymphoid cells with a large pleomorphic vesicular and hyperchromatic nuclei, with prominent nucleoli and a moderate amount of eosinophilic cytoplasm dermal large cells showed a cohesive growth pattern, forming large clusters, there were numerous mitotic figures. Immunohistochemical staining demonstrated CD30 and lca antigen expressions in >75% of the cells. T-cell immunophenotype also expressed the CD4 antigen. CD3, 5, 8, 20, 56, and anaplastic lymphoma kinase 1 were all negative chest radiography and CT scans of the chest, abdomen and pelvis were normal, bone marrow exam was not performed, all lab tests and imaging didnt reveal any extracutaneous involvement
Remission Characteristics
The lesion disappeared during hematological consultation after the incisional skin biopsy, completely regression was observed within a week, only faint pigmentation remained at the lesion site a control biopsy was performed and there were no histological features of lymphoma there was no reoccurrence in the 10 months follow up period
Treatment & Mechanisms
Proposed Remission Mechanisms
Death receptor-mediated apoptosis
Clinical Treatment
None reported
Non-Clinical Treatment
None reported