Spontaneous Clinical Regression In Chronic Lymphocytic Leukaemia
Thomas, R., Ribeiro, I., Shepherd, P., Johnson, P., Cook, M., Lakhani, A., Kaczmarski, R., Carrington, P., & Catovsky, D. (2002). spontaneous clinical regression in chronic lymphocytic leukaemia. British journal of haematology, 116(2), 341–345. https://doi.org/10.1046/j.0007-1048.2001.03286.x
View Original Source →Abstract
. Chronic lymphocytic leukaemia (CLL) is a B‐cell disorder, which has a median survival of over 10 years from diagnosis for stage A disease. The natural history of stage A disease is generally indolent or only slowly progressive. It is less well known that CLL may undergo spontaneous regression. We report a series of 10 such cases (eight stage A and two stage B) followed at our institutions.
Case Details
Disease Location
Bone marrowithblood/ln
Personal Characteristics
47 -year-old male
Clinical Characteristics
In 1982 was noted to have lymphocytosis in 1983 the count peaked at 96x10^9/l, 90% were CD5/19 positive and demonstrated lambda light chain restriction he had cervical, axillary and inguinal lymphadenopathy, the largest being 2x2cm and a spleen that was just palpable
Remission Characteristics
The disease regressed over the next 18 years and when seen in feb 2000 he had a lymphocyte count of 14x10^9/l and no lymphadenopathy and splenomegaly over the last few months his lymphocyte count has risen to 27x10^9/l although he remains well with no organomegaly or lymphadenopathy
Treatment & Mechanisms
Proposed Remission Mechanisms
Possibility of a natural regulatory mechanism controlling b-cell cll, which in rare instances leads to a downregulation of cell proliferation and eventually to a durable clinical remission
Clinical Treatment
None reported
Non-Clinical Treatment
None reported