Spontaneous Clinical Regression In Chronic Lymphocytic Leukaemia
Thomas, R., Ribeiro, I., Shepherd, P., Johnson, P., Cook, M., Lakhani, A., Kaczmarski, R., Carrington, P., & Catovsky, D. (2002). spontaneous clinical regression in chronic lymphocytic leukaemia. British journal of haematology, 116(2), 341–345. https://doi.org/10.1046/j.0007-1048.2001.03286.x
View Original Source →Abstract
. Chronic lymphocytic leukaemia (CLL) is a B‐cell disorder, which has a median survival of over 10 years from diagnosis for stage A disease. The natural history of stage A disease is generally indolent or only slowly progressive. It is less well known that CLL may undergo spontaneous regression. We report a series of 10 such cases (eight stage A and two stage B) followed at our institutions.
Case Details
Disease Location
Bone marrowithblood/ln
Personal Characteristics
47 -year-old male
Clinical Characteristics
Presented in 1979 when routine count revealed a lymphocyte count of 124x10^9/l he had a 1x1cm bilateral cervical and inguinal lymphadenopathy and a spleen that was just palpable marrow aspirate revealed a heavy infiltrate of lymphocytes
Remission Characteristics
Over the next 20 years his lymphocyte counts gradually decreased without any treatment when last seen in aug 2000, he had a lymphocyte count of 13.3x10^9/l and no lymphadenopathy or splenomegaly
Treatment & Mechanisms
Proposed Remission Mechanisms
Possibility of a natural regulatory mechanism controlling b-cell cll, which in rare instances leads to a downregulation of cell proliferation and eventually to a durable clinical remission
Clinical Treatment
None reported
Non-Clinical Treatment
None reported