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Spontaneous Regression Of Metastatic Extraskeletal Myxoid Chondrosarcoma

Kinoshita et al., 2015Sarcoma

Kinoshita, T., Kamiyama, I., Hayashi, Y., Asakura, K., Ohtsuka, T., Kohno, M., Emoto, K., Nakayama, R., Morioka, H., & Asamura, H. (2015). spontaneous Regression of Metastatic Extraskeletal Myxoid Chondrosarcoma. The Annals of thoracic surgery, 100(4), 1465–1467. https://doi.org/10.1016/j.athoracsur.2014.12.107

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Abstract

Spontaneous regression of tumors is very unusual and is defined as a partial or complete disappearance of metastatic tumors without any treatment. This phenomenon has been reported in almost all types of cancer. The patient was a 25-year-old woman who presented with multiple pulmonary nodules on her bilateral lungs on the annual chest roentgenograph. Simultaneously, a swelling mass on her subcutaneous inguinal region was observed. The diagnosis of the inguinal mass was extraskeletal myxoid chondrosarcoma. The inguinal mass and pulmonary nodules spontaneously regressed without any treatment after biopsy. The patient was doing well without evidence of recurrence at 1 year after the operation without any additional therapy. Our case is the first clinical one that indicated a possibility of histologic regression of extraskeletal myxoid chondrosarcoma.

Case Details

Disease Location

Lung

Personal Characteristics

25-year-old woman

Clinical Characteristics

Presented with multiple pulmonary nodules on her bilateral lungs on the annual chest x-ray. Simultaneously, a swelling mass on her subcutaneous inguinal region was observed. The diagnosis of the inguinal mass was emc. The inguinal mass and pulmonary nodules spontaneously regressed without any treatment after biopsy, except for one lesion located on her right lower lobe, which regrew. Right lower lobectomy was performed. The pathologic diagnosis was confirmed as pulmonary metastasis of emc

Remission Characteristics

The inguinal mass and pulmonary nodules spontaneously regressed without any treatment after biopsy

Treatment & Mechanisms

Proposed Remission Mechanisms

Surgical biopsy triggered an immune response

Clinical Treatment

Biopsy right lower lobectomy