Spontaneous Regression Of Essential Thrombocythemia With Mpl Mutation On Menopause
Otsuka, M., Hanada, S., Arita, K., & Ohashi, H. (2014). spontaneous regression of essential thrombocythemia with MPL mutation on menopause. International journal of hematology, 99(5), 668–670. https://doi.org/10.1007/s12185-014-1544-8
View Original Source →Case Details
Disease Location
Skin/platelets
Personal Characteristics
45-year-old woman
Clinical Characteristics
Presented with purpura in may 2006, mild anemia, severe thrombocytosis. Myelography showed hypercellularity and an increased number of megakaryocytes. Bone marrow biopsy showed hypercellularity and an increased number of megakaryocytes, but atypia without hyperplasia of reticulin fibrosis was not observed. The patient was diagnosed with et. She was diagnosed with iron deficiency anemia due to excessive menstruation, and therefore, she received iron therapy. In february 2010, as she began to enter menopause, her hb level improved naturally. Mutation analysis by direct sequencing (ds) was performed on the patient’s granulocyte DNA obtained in december 2008 mpl mutation in codon 515 (mpl-w515-p518delinskt) was detected and reported. He same analysis did not detect the mutation in granulocytic DNA obtained in february 2011
Remission Characteristics
February 2011, her platelet count was normalized
Treatment & Mechanisms
Proposed Remission Mechanisms
No major mechanism proposed
Clinical Treatment
Aspirin iron therapy