Pontaneous Regression Of Cutaneous Blastic Plasmacytoid Dendritic Cell Neoplasm Followed By Acute Monocytic Leukemia Evolving From Myelodysplastic Syndrome
Yasuda, H., Takaku, T., Tomomatsu, J., Hosone, M., Tanaka, H., & Komatsu, N. (2014). spontaneous regression of cutaneous blastic plasmacytoid dendritic cell neoplasm followed by acute monocytic leukemia evolving from myelodysplastic syndrome. Internal medicine (Tokyo, Japan), 53(23), 2717–2720. https://doi.org/10.2169/internalmedicine.53.2740
View Original Source →Case Details
Disease Location
Skin, stomach
Personal Characteristics
67-year-old man
Clinical Characteristics
Presented with multiple erythematous nodules on the trunk and limbs. A skin biopsy revealed medium-sized blastoid cells infiltrating the dermis and subcutis but sparing the epidermis, diagnosis of blastic plasmacytoid dendritic cell neoplasm (bpdcn) was made. Upper gastrointestinal (gi) endoscopy revealed two polypoid lesions in the gastric corpus, he biopsy again revealed medium-sized blastoid cells infiltrating the lamina propria which showed the same marker expression pattern as the cutaneous bpdcn cells. A bone marrow (bm) evaluation revealed a blast count of 13.2% along with dysplastic features, such as micromegakaryocytes and nuclear hypolobation of granulocytes, suggesting concomitant mds. Was hospitalized in late march 2012 due to sudden hematemesis. Upper gi endoscopy showed multiple hemorrhagic ulcers in the gastric corpus, but a biopsy was not conducted due to the patient’s poor general condition. Evolution of mds to acute monocytic leukemia with morphology resembling acute myeloid leukemia-m5b was confirmed. He developed an acute immunerelated thrombocytopenia due to epatientifibatide, which required platelet transfusions.
Remission Characteristics
He skin lesions spontaneously regressed and complete diminishment
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed
Clinical Treatment
Idarubicin hydrochloride (after recurrence)