Spontaneous Regression Of Mantle Cell Lymphoma: A Report Of Four Cases
Ye, H., Desai, A., Gong, T., Zeng, D., Nomie, K., Chen, W., Wang, W., Romaguera, J., & Wang, M. L. (2018). spontaneous regression of mantle cell lymphoma: a report of four cases. Cancer communications (London, England), 38(1), 30. https://doi.org/10.1186/s40880-018-0306-z
View Original Source →Abstract
Spontaneous regression has been reported in some indolent forms of lymphoma. Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm and has a poor prognosis. However, approximately 30% of MCL patients can exhibit indolent clinical behavior. To date, complete spontaneous regression of MCL has not been reported. We describe four cases of spontaneous regression of MCL. At the time of presentation, these patients were asymptomatic, with lymph node enlargement and mild to moderate fluorodeoxyglucose (FDG) uptake on FDG-positron emission tomography combined with computed tomography. One of the possible mechanisms of spontaneous regression of the tumor could be due to the host immune response through humoral and cellular immunity, which may have a role in the clearance of tumor cells. In this report, we support the use of a “wait and watch” strategy for MCL patients with no risk factors and indolent behavior. This strategy helps spare patients from further potentially harmful chemotherapy. In addition, we describe the phenomenon of spontaneous regression in MCL patients who are asymptomatic and have low-volume disease.
Case Details
Disease Location
Inguinal lymph nodes, cervical triangle
Personal Characteristics
68 -year-old male
Clinical Characteristics
Mantle cell lymphoma (mcl) during surgery for iliac artery aneurysm in january 211, removal of enlarged inguinal lymph nodes took place pathology was reported as mcl with a mantle zone pattern and a ki-67 value of approx. 5% watch-and-wait was underwent in september 2011, cervical CT with contrast showed sub-centimeter lymph nodes at the left posterior triangle and PET-CT showed low-grade fdg-avidity at these nodes with an suv of 2.6 in the left posterior cervical triangle with minimal fdg activity in the bilateral inguinal lymph nodes
Remission Characteristics
In june 2015, follow-up PET-CT showed the fdg-avid area had regressed spontaneously on the last follow-up in july 2016, the patient showed no signs of mcl
Treatment & Mechanisms
Proposed Remission Mechanisms
The host immune response through humoral and cellular immunity may play a central role in the clearance of tumor cells and contribute to sr
Clinical Treatment
None reported
Non-Clinical Treatment
None reported