spontaneous regression of a primary cutaneous diffuse large B-cell lymphoma, leg type

Case Details

Disease Location

Left arm

Personal Characteristics

72 -year-old female no history of autoimmune diseases and was not on immunosuppressive medications

Clinical Characteristics

Primary cutaneous diffuse large b-cell lymphoma, leg type presented with a nodule on her upper left arm that had appeared 1 month earlier physical exam revealed a 3cm diameter solitary, hard, subcutaneous tumor with poor mobility on her upper left arm skin biopsy revealed a diffuse dermal infiltrate separate from the epidermis. It was composed of mono- and multinuclear large atypical lymphocytes with prominent nucleoli and frequent mitoses atyical cells were positive for CD20, cd79a, bcl-2, and mum-1 PET showed a 18x7x29mm mass on the left arm that coincided with the clinical location diagnosis of pcdlbcl-lt was made the shrunken tumor was then surgically removed histopathological evaluation showed a diffuse infiltrate comprised of a small number of atypical cells surrounded by many small lymphocytes the atypical cells were CD20 positive; the small lymphocytes were positive for CD3, 4, 8, perforin, granzyme b and t-cell-restricted intracellular antigen-1 there was no recurrence in the subsequent 21 month

Remission Characteristics

After the biopsy, the tumor had shrank there was no recurrence 21 month after the removal

Treatment & Mechanisms

Proposed Remission Mechanisms

May be attributable to an immune response to infectious microbes or to traumatic intervention ihc demonstrated lymphocytes positive for CD3,4, 8 and cytotoxic molecules, granzyme b and tia1. It could be that the cytotoxic molecules from cytotoxic t lymphocytes played a pivotal role in the sr

Clinical Treatment

Surgical removal of the tumor

Non-Clinical Treatment

None reported