Spontaneous Regression Of A Childhood Tumour With Anaplastic Histological Features
Biswas, A., & Tan, B. B. (2013). spontaneous regression of a childhood tumour with anaplastic histological features. Clinical and experimental dermatology, 38(3), 318–320. https://doi.org/10.1111/j.1365-2230.2012.04427.x
View Original Source →Case Details
Disease Location
Left areola
Personal Characteristics
8 -year-old female
Clinical Characteristics
Primary cutaneous anaplastic large cell lymphoma presented with a 6 week history of a solitary erythematous skin lesion adjacent to the left areola, it started as an itchy papule suspected to be an insect bite but progressed rapidly over 3 weeks physical exam found an area of erythematous induration with ulceration 20x10mm in size found on the skin of the chest and focally reaching the left areola the lesion failed to respond to courses of antibiotics and topical hydrocortisone acetate andjusidic acid treatment superficial pyoderma gangrenosum was suspected, incisional biopsy was taken histology saw a dense diffuse dermal infiltrate of very pleomorphic tumor cells with blastoid morphology was seen. These tumor cells had a t help cell immunophenotype and the membrane and golgi zone gave strong positive staining for CD30.
Remission Characteristics
Shortly after the biopsy, the lesion started regressing and healed spontaneously 6 years after initial presentation, the patient is disease free
Treatment & Mechanisms
Proposed Remission Mechanisms
Overexpression of CD30 ligand may play a major role in regression triggering apoptotic pathways
Clinical Treatment
Antibiotics, topical hydrocortisone and fusidic acid