Deep Spontaneous Molecular Remission In A Patient With Congenital Acute Myeloid Leukemia Expressing A Novel Moz-p300 Fusion Transcripatient
Ikawa, Y., Nishimura, R., Maeba, H., Fujiki, T., Kuroda, R., Noguchi, K., Fukuda, M., Mase, S., Araki, R., Mitani, Y., Sato, T., Terui, K., Ito, E., Kitabayashi, I., & Yachie, A. (2018). Deep spontaneous molecular remission in a patient with congenital acute myeloid leukemia expressing a novel MOZ-p300 fusion transcripatient. Leukemia & lymphoma, 59(10), 2497–2499. https://doi.org/10.1080/10428194.2018.1434885
View Original Source →Case Details
Disease Location
Skin
Personal Characteristics
Newborn girl
Clinical Characteristics
Presented with multiple skin nodules 1day after birth. Peripheral blood analysis showed a white blood cell count of 54.93x10^9/l with 50% blasts. Bone marrow aspiration revealed 44% blast- like immature monocytic cells. Surface marker analysis showed that leukemic cells expressed cd11b, CD13, and CD33, and a diagnosis of acute myeloid leukemia (fab m5b) was made. A skin biopsy revealed a diffuse dermal infiltration by leukemic cells that had the same phenotype as the blasts in the bone marrow.
Remission Characteristics
The skin nodules spontaneously regressed gradually, and the patient was in good general condition. The patient achieved complete remission by 3 months of age.
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed