Pyogenic Variant Of Primary Cutaneous Cd30+ Anaplastic Large-cell Lymphoma: Spontaneous Remission In A Young Adult
Hees, H., Geißler, E. M., Wolter, M., Lamos, C., Löser, C. R., & Dippel, E. (2017). Pyogenic variant of primary cutaneous CD30+ anaplastic large-cell lymphoma: spontaneous remission in a young adult. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 15(9), 952–955. https://doi.org/10.1111/ddg.13315
View Original Source →Case Details
Disease Location
Left alar base (nose)
Personal Characteristics
20 -year-old male
Clinical Characteristics
Pyogenic variant of primary cutaneous CD30+ anaplastic large-cell lymphoma presented with fast-growing, ulcerated tumor, measuring approx. 3cm at the left alar base the lesion had development over the preceding 2 weeks and was not associated with pain or fever. There was tender left submandibular and cervical lymphadenopathy bacterial swab showed massive colonization with staphylococcus aureus MRI of the skull revealed a lesion at the ipsilateral nasal ala with marked perilesional edema extending to the infraorbital and mandibular region. Additionally, enlarged reactive ln were noted in the left cervical and submandibular regions histology revealed a deep, necrotizing lesion marked by granulocytic infiltration extending to the bottom of the specimen, there was also a diffuse, predominantly perivascular, deep pleomorphic infiltrate made up of medium-sized blast cells, histiocytes, and a few eosinophils. Ihc showed a majority of cells expressed CD3 with approx. 75% of the infiltrate also expression CD30. Only a few cells were CD20+. Clonality only revealed one clonal t-cell population systemic cefuroxime was started
Remission Characteristics
During diagnostic workup, the lesion started to improve after 4 weeks, the lesion completely resolved 4 months later the patient was still in complete remission
Treatment & Mechanisms
Proposed Remission Mechanisms
No major mechanism proposed
Clinical Treatment
Cefuroxime
Non-Clinical Treatment
None reported