Spontaneous Remission Of Adult Acute Myeloid Leukemia With T(8;16)(p11;p13)/moz-cbp Fusion
Hoshino, T., Taki, T., Takada, S., Hatsumi, N., & Sakura, T. (2018). spontaneous remission of adult acute myeloid leukemia with t(8;16)(p11;p13)/MOZ-CBP fusion. Leukemia & lymphoma, 59(1), 253–255. https://doi.org/10.1080/10428194.2017.1320712
View Original Source →Abstract
The translocation t(8;16)(p11;p13), which results in fusion of the MOZ/MYST3/KAT6A gene (8p11) and CBP/CREBBP gene (16p13), is characterized by unique morphologic and clinical findings in acute mye...
Case Details
Disease Location
Bone marrowithblood
Personal Characteristics
49-year-old woman
Clinical Characteristics
Presented for an annual checkup, at which a very high white blood cell count of 74.9x10^9l and a ldh level of 1575iu/l. Bone marrow aspiration revealed hypercellularity with an increased number of blasts (52.0%), which showed a monocytic appearance with heavy granulation upon dual myeloperoxidase and nonspecific esterase cytochemical staining. She was therefore diagnosed as having acute myeloid leukemia (fab m5a)
Remission Characteristics
Six days later, peripheral blood analysis showed a wbc count of 4.1x 10^9/l with normal wbc differentiation, and the serum ldh level was within the normal limits without treatment. She spontaneously underwent cr 7 days after diagnosis of the disease and stayed in remission
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed
Clinical Treatment
Bone marrow transplantation and total body irradiation and cyclophosphamide with tracolimus (after scr),