Apparent Spontaneous Regression Of Malignant Neoplasms After Radiography: Report Of Four Cases
Sasaki, J., Kurihara, H., Nakano, Y., Kotani, K., Tame, E., & Sasaki, A. (2016). Apparent spontaneous regression of malignant neoplasms after radiography: report of four cases. International journal of surgery case reports, 25, 40–43. https://doi.org/10.1016/j.ijscr.2016.05.049
View Original Source →Abstract
INTRODUCTION: On rare occasions, an apparently spontaneous regression of unknown etiology is observed in a neoplasm. We report a series of 4 patients with apparent spontaneous regression of malignant lymphomas after radiography. PRESENTATION OF CASE: All four of the tumors were malignant lymphomas. The regressions occurred between 1 and 2 months after the radiographic examinations. All four patients later underwent relapse and needed additional treatments: surgery, chemotherapy and/or radiation. DISCUSSSION: Four cases had the following features in common: (1) the neoplasms were radiosensitive, (2) the regression occurred after radiography, (3) none of the neoplasms was in the advanced stage, and (4) the doses received through radiographic exposure were a little higher than usual because CT was included for most of the patients. CONCLUSION: We suspect that the apparently spontaneous regression of malignant lymphomas was caused by the small radiation doses received in the radiographic examinations.
Case Details
Disease Location
Patient 3) front of neck, left lobe of the thyroid
Personal Characteristics
51 -year-old female
Clinical Characteristics
Left lobe of the thyroid was hard and smooth and was enlarged to 5x8cm malignant thyroid lymphoma was suspected but the fnab diagnosis was class ii, thyroid adenoma was diagnosed the nodule was very large and was located inferiorly so CT was used to confirm the extent of goiter. The CT showed that the goiter was situated partially intrathoracically after the tumor shrunk, it reappeared 7 months after the CT (5 months after the disappearance), it regrew to be slightly larger than the original size fnab revealed a potentially malignant lymphoma total thyroidectomy was performed 7 months after the first visit. Histological diagnosis was malignant diffuse large-cell lymphoma a fibrosis was found by microscopy post-op chemo (6 course of r-thp-cop) was given
Remission Characteristics
The tumor unexpected shrunk and had disappeared 2 months after the CT 8 years after the operation, the patient is well and with no recurrence
Treatment & Mechanisms
Proposed Remission Mechanisms
The lymphoma was radiosensitive, and size was reduced due to small-dose radiation from radiographic procedures
Clinical Treatment
Thyroidectomy 6 courses of r-thp-cop
Non-Clinical Treatment
None reported