Spontaneous Remission In Patients With Acute Myeloid Leukemia With T(8;21) Or Cutaneous Myeloid Sarcoma: Two Case Reports And A Review Of The Literature
Zeng, Q., Yuan, Y., Li, P., & Chen, T. (2013). spontaneous remission in patients with acute myeloid leukemia with t(8;21) or cutaneous myeloid sarcoma: two case reports and a review of the literature. Internal medicine (Tokyo, Japan), 52(11), 1227–1233. https://doi.org/10.2169/internalmedicine.52.9505
View Original Source →Abstract
Spontaneous remission (SR) in patients with acute myeloid leukemia (AML) is rare. We herein present two such cases. The first case was of AML-M2 accompanied by a bone marrow cytogenetic analysis revealing 46, XY, t(8;21)(q22,q22). The second case was of isolated cutaneous myeloid sarcoma (MS) that progressed to AML within seven months. Both of the patients had symptoms of infection and anemia and were therefore treated with antibiotics and transfusions. The SR lasted for two months and one month, respectively. Currently, the mechanisms underlying SR remain ambiguous. Possible underlying mechanisms with a review of the related literature are discussed.
Case Details
Disease Location
Bone marrowithskin
Personal Characteristics
34-year-old woman, she had undergone resection of an astrocytoma in the right side of the brain at 8 years of age.
Clinical Characteristics
Mass on her left upper arm lasting for seven months and a five-day history of petechiae on her entire body. Physical examination revealed combined aphasia and tongue extension difficulty. The classification of the nucleated cells in the peripheral blood was 72% myeloblasts, 10% myelocytes and 10% metamylocytes. A cranial CT scan showed a softening focus after the astrocytoma surgery concomitant with a cerebral hematoma on the left side. The patient developed a high fever (more than 38.5°c)
Remission Characteristics
As the patient was first admitted to the department of neurology, the bm aspiration was delayed to the end of november 2000, at which time it showed no myeloblasts
Treatment & Mechanisms
Proposed Remission Mechanisms
Immune responses
Clinical Treatment
Dilantin and sodium valproate therapy for a long period cephalosporin and ciprofloxacin
Non-Clinical Treatment
None reported