Spontaneous Regression Of Gastric Lymphoma
Strauchen, J. A., Moran, C., Goldsmith, M., & Greenberg, M. (1987). spontaneous regression of gastric lymphoma. Cancer, 60(8), 1872–1875. https://doi.org/10.1002/1097-0142(19871015)60:8<1872::aid-cncr2820600833>3.0.co;2-6
View Original Source →Abstract
Two cases of spontaneous regression of histologically diagnosed large cell lymphoma of the stomach are reported. Regressions occurred after nonspecific therapy including the H-2 antagonist cimetidine and were documented surgically. Spontaneous regression of intermediate and high-grade non-Hodgkin's lymphoma is distinctly uncommon. The possible role of cimetidine in these cases is discussed.
Case Details
Disease Location
Gi
Personal Characteristics
73 -year-old male
Clinical Characteristics
Presented with a 3.5 months history of epigastric discomfort and 1.4-1.8kg weight loss. Upper gi endoscopy demonstrated a large irregular antral ulcer with thickened gastric folds endoscopic biopsy showed malignant lymphoma abdominal CT showed changes consistent with lymphomatous infiltration of the stomach the patient was started on cimetidine and antacids which were continued until surgery. The surgery was delayed 14 weeks. An upper gi series performed 3 weeks before surgery demonstrated persistent antral ulceration at surgery, an antral ulcer was found, a partial gastrectomy and liver biopsy was performed endoscopic biopsy specimens showed a diffuse infiltrate of large atypical lymphoid cells. Focally, necrosis and ulceration were present, histologic findings were those of malignant lymphoma, diffuse, large cell the gastric resection consisted of a subtotal gastrectomy measuring 15cm in length along the greater curvature with a single smooth margined ulceration in the antral region, microscopic exam revealed a mucosal infiltrate of small, mature lymphocytes with germinal centers
Remission Characteristics
After surgery, no tumor recurrence has been noted for 16 months, no further therapy was given
Treatment & Mechanisms
Proposed Remission Mechanisms
Regression occurred following h-2 anatgonist therapy perhaps an immunomodulatory role, enhancement of NK cell activity
Clinical Treatment
Cimetidine and antacids subtotal gastrectomy
Non-Clinical Treatment
None reported