Late Recurrence In Hodgkin's Disease: A Report Of Two Cases
Green, J. A., Arnold, A. M., Macbeth, F. R., Mead, G. M., Williams, C. J., Wright, D. H., & Whitehouse, J. M. (1984). Late recurrence in Hodgkin's disease: a report of two cases. Medical and pediatric oncology, 12(2), 148–149. https://doi.org/10.1002/mpo.2950120218
View Original Source →Abstract
Two cases of Hodgkin's disease are described who relapsed 22 and 19 years after regional radiation therapy. One of the patients also developed a carcinoma of the large bowel soon after first relapse. The importance of long follow‐up and documentation of cause of death in Hodgkin's disease is stressed.
Case Details
Disease Location
Bilateral cervical and axillary, mediastinal nodes
Personal Characteristics
48 -year-old female
Clinical Characteristics
Presented in april 1952 with bilateral cervical and axillary lymphadenopathy, and enlarged mediastinal nodes shown on a chest xray a biopsy of a left cervical node mass was shown to be infiltrated by hodgkin's disease when initially stable, her condition deteriorated over the next year with fever, sweating and weight loss. Local radiotherapy was given to her neck, axilla and mediastinum in 7 fractions over 10 days. In 1975 she noted increasing right cervical adenopathy becoming painful and later associated with generalized pruritus but not other symptoms by september 1979, the mass had extended over the right upper anterior chest wall to the level of the 4th rib and infiltrated the overlying skin. Nodes were present in the right axilla and chest xray showed widening of the mediastinum a biopsy was taken and compared with the biopsy obtained in 1952; both showed the features of nudular sclerosing hodgkin's disease she was considered to be stage iib as the relapse was within a previously irradiated area, chemo with chlorambucil, vinblastine, procarbazine and prednisolone was given with good response in february 1981, she developed a large bowel obstruction, laparotomy found a carcinoma of the ascending colon with hepatic metastases but no evidence of hodgkin's she died a months later relapse occured at 22 years later
Remission Characteristics
After local radiotherapy, she remained well until 1975 chemo in 1979 resulted in a good response and she remained in complete remission until february 1981
Treatment & Mechanisms
Proposed Remission Mechanisms
No major mechanism proposed
Clinical Treatment
Local radiotherapy chemo (chlorambucil, vinblastine, procarbazine, and prednisolone)
Non-Clinical Treatment
None reported