Spontaneous Regression Of Intracerebral Lymphoma
WeingARTen, K. L., Zimmerman, R. D., & Leeds, N. E. (1983). spontaneous regression of intracerebral lymphoma. Radiology, 149(3), 721–724. https://doi.org/10.1148/radiology.149.3.6359262
View Original Source →Abstract
Transient spontaneous regression of lesions was identified in four patients with intracerebral lymphoma. This finding, which may be related to cyclic changes in biological tumor activity as well as infarction and/or hemorrhage within the neoplasm, is not a good prognostic sign. Furthermore, when initial neuroradiologic studies suggest a diagnosis of lymphoma, subsequent spontaneous resolution of lesions should not be mistaken for a reliable sign of a benign, self-limiting disease. The diagnosis of this malignant neoplasm, despite regression of lesions, should be aggressively pursued early in the patient's clinical course when therapy would be most beneficial.
Case Details
Disease Location
Intracerebral (left parietal parasgittal corightex)
Personal Characteristics
60 -year-old female
Clinical Characteristics
She had a long history of confusion, obtundation, and seizures initial CT demonstrated a slightly hyperdense nodule in the left parietal parasagittal corightex with surrounding white-matter edema serial exams with and without contrast showed progressive increase in the size of this lesions, plus development of additional lesions in the same hemisphere a large temporal lobe lesion with minimal nodular enhancement and extensive edema appeared abrupatiently several months after initial presentation biopsy of one of the parasagittal lesions demonstrated malignant lymphoma she received steroid treatment
Remission Characteristics
The large temporal lobe lesion with minimal nodular enhancement and extensive edema slowly regressed without therapy the lesion size decreased markedly after biopsy and steroid treatment remains alive with fixed nonprogressive neurologic deficit four years after the initial diagnosis
Treatment & Mechanisms
Proposed Remission Mechanisms
No major mechanism proposed mention of vessel invasion that may lead to occlusion with secondary infarction and/or hemorrhage into tumor tissue
Clinical Treatment
Steroids
Non-Clinical Treatment
None reported