Spontaneous Regression Of Intracerebral Lymphoma
WeingARTen, K. L., Zimmerman, R. D., & Leeds, N. E. (1983). spontaneous regression of intracerebral lymphoma. Radiology, 149(3), 721–724. https://doi.org/10.1148/radiology.149.3.6359262
View Original Source →Abstract
Transient spontaneous regression of lesions was identified in four patients with intracerebral lymphoma. This finding, which may be related to cyclic changes in biological tumor activity as well as infarction and/or hemorrhage within the neoplasm, is not a good prognostic sign. Furthermore, when initial neuroradiologic studies suggest a diagnosis of lymphoma, subsequent spontaneous resolution of lesions should not be mistaken for a reliable sign of a benign, self-limiting disease. The diagnosis of this malignant neoplasm, despite regression of lesions, should be aggressively pursued early in the patient's clinical course when therapy would be most beneficial.
Case Details
Disease Location
Intracerebral (frontal lobe)
Personal Characteristics
69 -year-old female
Clinical Characteristics
She had a 6 week history of gait difficulty, strange behavior and fainting. Initial CT demonstrated bifrontal hyperdense parasagittal corightical lesions with surrounding white-matter edema slight enhancement was seen after infusion of contrast material serial CT scans without treatment were conducted despite improvement in the cts, the patient's clinical condition progressively deteriorated and she died 4 months after initial presentation autopsy demonstrated poorly differentiated malignant lymphocytic lymphoma in the frontal lobe
Remission Characteristics
The serial cts demonstrated a decrease in size, denisty and enhancement of the lesions, and regression of the white-matter edema
Treatment & Mechanisms
Proposed Remission Mechanisms
No major mechanism proposed mention of vessel invasion that may lead to occlusion with secondary infarction and/or hemorrhage into tumor tissue
Clinical Treatment
None reported
Non-Clinical Treatment
None reported