Cutaneous Lymphoblastoma: report of two Cases with Unusual Courses

Case Details

Disease Location

Cutaneous (back)

Personal Characteristics

36 -year-old male

Clinical Characteristics

"first seen 8 months previously due to the presence of tumoral masses for a duration of 2 months many subcutaneous nodular tumors no larger than 3cm in diameter, firmly adhering to the dermis on the back were seen biospy read large masses of tumor cells occupying the middle and lower part of the dermis, at some places being separated form the epidermis by a thin layer of connective tissue the predominating cell was lymphoblastic, lymphocytes were seen in moderate numbers treated with corticosteroids and general reinforcement therapy he was not seen until 6 months later, during that time he did not have any treatment new tumors appear, now on the face and neck where an ulceration had also formed, the skin was slightly under the level of the other skin the right cervical and retrosternocleidomastoid glands were enlarged x-ray therapy was applied and cytostatic ""endoxan"" was given two biopsies were made, one from a growing tumor and one from the involuted tumor pathohistologic findings in the growing tumor were similar to previously examined specimen; thin reticular fibers surround the cellular infiltrates pathohistologic exam of the involuted tumor showed the epidermis to be slightly atrophic with the rete pegs flattened. Adjacent to the surface of the collagen bundles, partly basophilic, fibroblasts in greater numbers were seen. Among the collagen bundles, mainly perivascular, periglandular and round the pilosebaceous unit, lymphoblasts, lymphocytes, and hystiocytes were seen smears of the involuted tumor showed lymphoctyes in small numbers with occasional lymphoblasts"

Remission Characteristics

When the new neck and face tumors appeared, the back tumors had completely regressed sr was evidence histologically by an increased growth of fibroblasts and greater amounts of collagen bundles among which lymphoid cells and histiocytes were seen

Treatment & Mechanisms

Proposed Remission Mechanisms

Regression of neoplasms during radiation, antimitotic and hormonal therapy, is party ascribed to connective tissue alteration

Clinical Treatment

Corticosteroids and general reinforcement therapy x-ray therapy and cytostatic endoxan

Non-Clinical Treatment

None reported