Spontaneous Regression Of Primary Malignant Lymphoma Of The Stomach In Two Nontreated Japanese
Shigematsu, A., Iida, M., Lien, G. S., Imamura, T., Okada, M., Fuchigami, T., Fujishima, M., Itoh, H., & Iwashita, A. (1989). spontaneous regression of primary malignant lymphoma of the stomach in two nontreated Japanese. Journal of clinical gastroenterology, 11(5), 511–517. https://doi.org/10.1097/00004836-198910000-00006
View Original Source →Abstract
Two patients with primary malignant lymphoma underwent spontaneous regression. One was a 40-year-old woman with a large ulcerating tumor on the greater curvature of the gastric antrum. This tumor shrank spontaneously, leaving only a small shallow ulcer. The resected specimen showed a minute focus of malignant lymphoma in the ulcer base. The other was a 73-year-old man who had a tumor with central ulceration on the posterior wall of the gastric antrum. Endoscopic biopsy revealed a malignant lymphoma. This tumor disappeared 60 days later. The patient refused surgery and remains well with no evidence of recurrent disease at this writing, 44 months later. Although there have been several case reports of spontaneous regression, partial or complete, of gastric malignant lymphoma, our cases seem to be the ones best proven.
Case Details
Disease Location
Poster wall of the antrum
Personal Characteristics
73 -year-old male japanese
Clinical Characteristics
Complained of abdominal pain gastroscopy revaluationed a protuberant tumor with a shallow ulcer and a smooth mucosal surface on the posterior wall of the antrum blood clot was evident on the ulcer base endoscopic biospy revaluationed malignant lymphoma cells, positive for intracytoplasmic immunoglobulins with a monoclonal pattern (IGG, lambda type) histologic diagnosis of malignant lymphoma, large cell type was made following a barium meal, a polypoid mass with a smooth mucosal surface and central ulceration was detected and he was admitted CT, ga67, and ultrasound indicated no lymphomatous lesion outside of the stomach
Remission Characteristics
21 days after the first exam, gastroscopy revealed that the tumor had decreased in size, even though chemotherapy or radiotherapy had not been given 40 days later, a double-contrast upper gi study revealed slight fold convergency, suggesting a healed ulcer on the posterior wall of the pyloric antrum on a compression study, the tumor with the central ulceration had almost entirely disappeared gastroscopy performed 60 days after the initial examination also showed the disappearance of the tumor with the central ulcer a discolored area was present where the tumor had been the endoscopically obtained biopsy specimens showed no malignant cells careful follow-up including a gastroscopy with biopsy showing only erosive gastritis 8 months later recent barium studies of the upper gi tract showed no sign of recurrent disease 44 months after the tumor disappeared
Treatment & Mechanisms
Proposed Remission Mechanisms
No major mechanism proposed
Clinical Treatment
None reported
Non-Clinical Treatment
None reported