Spontaneous Regression Of Non-hodgkin's Lymphoma
Krikorian, J. G., Porightlock, C. S., Cooney, P., & Rosenberg, S. A. (1980). spontaneous regression of non-Hodgkin's lymphoma: a report of nine cases. Cancer, 46(9), 2093–2099. https://doi.org/10.1002/1097-0142(19801101)46:9<2093::aid-cncr2820460931>3.0.co;2-4
View Original Source →Abstract
Two hundred and nine cases of non-Hodgkin's lymphoma have been analyzed retrospectively for the occurrence of spontaneous regression (SR). Complete, partial or minor SR was found in 18 out of 140 cases with nodular lymphoma and in 2 out of 69 cases with diffuse lymphoma. Thus, SR occurs far more frequently in nodular lymphoma than in the diffuse type. Within the nodular lymphoma group, SR is associated with long survival. It occurred in previously treated and untreated patients and in nodal and extranodal disease; the duration varied from a few weeks to many years but lasted one year or more in 7 cases with complete or partial SR.
Case Details
Disease Location
Bilateral cervical, supraclavicular, axillary, and inguinal, and right iliac mass
Personal Characteristics
43 -year-old female
Clinical Characteristics
She visited with the notice of waxing and waning generalized lymphadenopathy over the previous 9 years over the alst 2 months her axillary lymph nodes began enlarging prior to her referral a left axillary ln biopsy showed nodular poorly differentiated lymphocytic lymphoma she was noted to have bilateral cervical, supraclavicular, axillary, and inguinal lymphadenopathy and right iliac mass chest roentgenogram and full lung tomography revealed bilateral hilar, tracheobronchial, and paratracheal lymphadenopathy bone marrow biopsy revealed involvement with poorly differentiated lymphocytic lymphoma lymphogram demonstrated bulky bilateral pelvic and para-aortic lymphadenopathy IV pyelogram demonstrated a lobulated course of both ureters consistent with lymphadenopathy but no evidence of obstruction she was staged IV m+a
Remission Characteristics
4 months later, her peripheral lymphadenopathy was noted to regress chest roentgenogram demonstrated reduction of the hiar and paratracheal lymphadenopathy and lymphogram showed reduction in the size of the opacified lymph nodes partial regression of her lymphadenopathy continued for 14 months subsequently, her generalized lymphadenopathy began to enlarge slowly 32 months following her initial visit, she has not yet required therapy
Treatment & Mechanisms
Proposed Remission Mechanisms
Host immunity, local host or environment factors, diagnostic tools may affect the course of the disease
Clinical Treatment
None reported
Non-Clinical Treatment
None reported