Spontaneous Regression Of Non-hodgkin's Lymphoma
Krikorian, J. G., Porightlock, C. S., Cooney, P., & Rosenberg, S. A. (1980). spontaneous regression of non-Hodgkin's lymphoma: a report of nine cases. Cancer, 46(9), 2093–2099. https://doi.org/10.1002/1097-0142(19801101)46:9<2093::aid-cncr2820460931>3.0.co;2-4
View Original Source →Abstract
Two hundred and nine cases of non-Hodgkin's lymphoma have been analyzed retrospectively for the occurrence of spontaneous regression (SR). Complete, partial or minor SR was found in 18 out of 140 cases with nodular lymphoma and in 2 out of 69 cases with diffuse lymphoma. Thus, SR occurs far more frequently in nodular lymphoma than in the diffuse type. Within the nodular lymphoma group, SR is associated with long survival. It occurred in previously treated and untreated patients and in nodal and extranodal disease; the duration varied from a few weeks to many years but lasted one year or more in 7 cases with complete or partial SR.
Case Details
Disease Location
Right posterior cervical, right posterior auricular, right submandiibular, bilateral axillary
Personal Characteristics
68 -year-old female
Clinical Characteristics
First visited with a 4 months history of asymptomatic right posterior cervical lymphadenopathy previous biopsy of a ln had revealed nodular poorly differentiated lymphocytic lymphoma physical exam revealed right posterior auricular, right submandibular, left anterior cervical, and bilateral axillary lymphadenopathy chest roentgenogram showed a left hilar mass bone marrow biopsy revealed involvement with lymphocytic lymphoma and lymphogram revealed enlarged, foamy bilateral para-aortic and iliac lymph nodes, compatible withtumor involvement she was staged IV m+a
Remission Characteristics
3 months later, it was noted that her peripheral lymphadenopathy had regressed the left hilar mass on chest roentgenogram resolved and the abdominal lymphogram demonstrated marked reduction in the size of the involved lymph nodes she continues asymptomatic without therapy and without clinical evidence of disease 2 years after her visit
Treatment & Mechanisms
Proposed Remission Mechanisms
Host immunity, local host or environment factors, diagnostic tools may affect the course of the disease
Clinical Treatment
None reported
Non-Clinical Treatment
None reported