Spontaneous Regression Of Non-hodgkin's Lymphoma
Krikorian, J. G., Porightlock, C. S., Cooney, P., & Rosenberg, S. A. (1980). spontaneous regression of non-Hodgkin's lymphoma: a report of nine cases. Cancer, 46(9), 2093–2099. https://doi.org/10.1002/1097-0142(19801101)46:9<2093::aid-cncr2820460931>3.0.co;2-4
View Original Source →Abstract
Two hundred and nine cases of non-Hodgkin's lymphoma have been analyzed retrospectively for the occurrence of spontaneous regression (SR). Complete, partial or minor SR was found in 18 out of 140 cases with nodular lymphoma and in 2 out of 69 cases with diffuse lymphoma. Thus, SR occurs far more frequently in nodular lymphoma than in the diffuse type. Within the nodular lymphoma group, SR is associated with long survival. It occurred in previously treated and untreated patients and in nodal and extranodal disease; the duration varied from a few weeks to many years but lasted one year or more in 7 cases with complete or partial SR.
Case Details
Disease Location
Right submandibular, right epitrochlear, left axillary, right inguinal and right femoral regions
Personal Characteristics
42 -year-old male
Clinical Characteristics
Presented in march 1973 with lymphadenopathy measuring up to 2cm involving the right submandibular, right epitrochlear, left axillary, right inguinal and right femoral regions. Biopsy of a right submandibular and right epitrochlear ln showed nodular mixed lymphocytic and histiocytic lymphoma lymphogram was performed in june 1973 and showed markedly enlarged foamy lymph nodes in the para-aortic and common iliac regions bilaterally a repeat chest roentgenogram following the lymphogram revealed an abnormal foamy node in the left supraclavicular region he was staged as iii-a and was observed without therapy
Remission Characteristics
2 months following his lymphogram, peripheral lymphadenopathy was noted to regress 4 months following his lymphogram, he had no evidence of disease on physical exam and the previously abnormal lymph nodes observed on the abdominal lymphogram and chest roentgenogram had regressed showing equivocal abnormalities but no definite evidence of lymphoma he has continued asymptomatic and without evidence of disease 5 years since his initial diagnsis
Treatment & Mechanisms
Proposed Remission Mechanisms
Host immunity, local host or environment factors, diagnostic tools may affect the course of the disease
Clinical Treatment
None reported
Non-Clinical Treatment
None reported