The Virus Of Venezuelan Equine Encephalomyelitis As An Antineoplastic Agent In Man
TIGErightT, W. D., CROSBY, W. H., BERGE, T. O., HOWIE, D. L., KRESS, S., DANGERFIELD, H. G., BASS, J. W., & FRANK, W. (1962). The virus of Venezuelan equine encephalomyelitis as an antineoplastic agent in man. Cancer, 15, 628–632. https://doi.org/10.1002/1097-0142(196205/06)15:3<628::aid-cncr2820150326>3.0.co;2-a
View Original Source →Case Details
Disease Location
Lymph nodes
Personal Characteristics
38 -year-old male
Clinical Characteristics
Patient first noted a painless adenopathy in the right inguinal region, the neck, and the axilla in june 1857. Lymphosarcoma was diagnosed via biopsy in september 1957, marked splenomegaly was recorded irradiation was given to the mediastinum, both supraclavicular areas and the right inguinal area in february 1960, because of progression of adenopathy, he was given IV cyclophosphamide, with good response in november 1960, oral cyclophasphamide was started, and dosages tapered weekly until a maintainance dosage which continued until march 6, 1961 at that time, the spleen was found to extend to the level of the umbilicus and there were numerous enlarged anterior and posterior cervical nodes bilaterally, an enlarged right epitrochlear node, and numberous matted nodes in both bicipital grooves and both inguinal areas only major complaint of the patient was pruritis aggravated by bathing. Leukocyte count averaged 5k/mm^3, and platelet counts averaged 120k/mm^3 he was given tc-80 virus on march 20, 1961. His temperature was elevated sightly on march 22 and there was a 36 hour period of fever with a max of 102.8f that was reached on march 25th. Complaints were limited to mild headache and muscular pains during the fever period. Lowest leukocyte count was recorded on march 26 and a platelet count of 75k/mm^3 was obtained on march 28th cervical ln biopsy specimens were obtained in september 1957, march 28, 1961, and april 17, 1961. The original biopsy showed a very cellular tumor composed principally of lymphocytes. The material obtained postinoculation was less cellular, and there were numberous large cells with ill defined cytoplasmic borders and large pale nuclei. Some were multinucleated and bore some resemblance to rs cells
Remission Characteristics
Regression in the size of the nodes was noted after irradiation leukocyte and platelet counts returned to preinoculation levels with 2 weeks on april 4th, some decrease in spleen size was noted; by april 17 the spleen was no longer palpable, there were no change in lymph nodes on return exam on may 1, 1961, recession in the size of most of the superficial nodes were found. The average decrease in their diameters was 1/3 to 1/2 and some nodes were no longer palpable he said that the pruritis had disappeared some further regression of nodes was noted on june 19 (3 monthsts postinoculation) and the spleen was no palpable. He had no complaints and worked regularly
Treatment & Mechanisms
Proposed Remission Mechanisms
Inoculation with tc-80 virus resulted in objective evidence of tumor regression
Clinical Treatment
Irradiation IV cyclophasphamide, oral cyclophasphamide tc-80 virus
Non-Clinical Treatment
None reported